5-Bromopyridine-3-boronic acid
5-Bromopyridine-3-boronic acid
CAS: 452972-09-7
Molecular Formula: C5H5BBrNO2
5-Bromopyridine-3-boronic acid - Names and Identifiers
5-Bromopyridine-3-boronic acid - Physico-chemical Properties
| Molecular Formula | C5H5BBrNO2 |
| Molar Mass | 201.81 |
| Density | 1.78±0.1 g/cm3(Predicted) |
| Melting Point | >300°C |
| Boling Point | 351.5±52.0 °C(Predicted) |
| Flash Point | 166.4°C |
| Vapor Presure | 1.52E-05mmHg at 25°C |
| BRN | 9119873 |
| pKa | 5.91±0.10(Predicted) |
| Storage Condition | Keep Cold |
| Refractive Index | 1.602 |
5-Bromopyridine-3-boronic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Note | Irritant/Keep Cold |
| Hazard Class | IRRITANT |
5-Bromopyridine-3-boronic acid - Introduction
5-Bromopyridine-3-boronic acid is an organic compound with the chemical formula C5H5BBrNO2.
Nature:
-Appearance: White to light yellow solid.
-melting point: about 160~164 ℃.
-Solubility: Soluble in water, ethanol and dichloromethane.
Use:
- 5-Bromopyridine-3-boronic acid is often used in organic synthesis as an important organic synthesis reagent.
-It can be used to synthesize other organic compounds, such as drugs, pesticides, dyes, etc.
Preparation Method:
5-Bromopyridine-3-boronic acid has many preparation methods, one of which is commonly used to obtain by the reaction of sodium borohydride and 5-bromopyridine. Specific steps are as follows:
1. Add nonpolar solvents such as 5-bromopyridine and xylene into the reaction flask.
2. Add sodium borohydride and stir the reaction mixture under inert atmosphere.
3. After the reaction is completed, the product is obtained by filtration.
4. Gentle evaporation of the solvent gave 5-Bromopyridine-3-boronic acid as a white solid.
Safety Information:
- 5-Bromopyridine-3-boronic acid generally has low toxicity under normal conditions of use.
-Avoid skin contact and inhalation when in contact. In case of accidental contact, rinse immediately with water.
-Wear personal protective equipment such as gloves, glasses and lab coats during operation.
-Observe safe operating procedures when using and storing, and keep away from ignition and oxidizing agents.
Nature:
-Appearance: White to light yellow solid.
-melting point: about 160~164 ℃.
-Solubility: Soluble in water, ethanol and dichloromethane.
Use:
- 5-Bromopyridine-3-boronic acid is often used in organic synthesis as an important organic synthesis reagent.
-It can be used to synthesize other organic compounds, such as drugs, pesticides, dyes, etc.
Preparation Method:
5-Bromopyridine-3-boronic acid has many preparation methods, one of which is commonly used to obtain by the reaction of sodium borohydride and 5-bromopyridine. Specific steps are as follows:
1. Add nonpolar solvents such as 5-bromopyridine and xylene into the reaction flask.
2. Add sodium borohydride and stir the reaction mixture under inert atmosphere.
3. After the reaction is completed, the product is obtained by filtration.
4. Gentle evaporation of the solvent gave 5-Bromopyridine-3-boronic acid as a white solid.
Safety Information:
- 5-Bromopyridine-3-boronic acid generally has low toxicity under normal conditions of use.
-Avoid skin contact and inhalation when in contact. In case of accidental contact, rinse immediately with water.
-Wear personal protective equipment such as gloves, glasses and lab coats during operation.
-Observe safe operating procedures when using and storing, and keep away from ignition and oxidizing agents.
Last Update：2024-04-09 02:00:46
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CAS: 452972-09-7
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QQ: 56860987
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CAS: 452972-09-7
Tel: 0086-13605431940
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Mobile: +86-13605431940
QQ: 56860987
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